发明名称 Aza-heterocyclic compounds used to treat neurological disorders and hair loss
摘要 This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres represented by formula (I), their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth. In said formula, n is 1-3; X is either O or S; R1 is selected from the group consisting of C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, aryl, heteroaryl, carboncycle, or heterocycle; D is a bond, or a C1-C10 straight or branched chain alkyl, C2-C10 alkenyl or C2-C10 alkynyl; R is as defined in the application.
申请公布号 AU1708199(A) 申请公布日期 1999.12.20
申请号 AU19990017081 申请日期 1998.12.03
申请人 GUILFORD PHARMACEUTICALS INC.;AMGEN INC 发明人 GREGORY S. HAMILTON;MARK H. NORMAN;YONG-QIAN WU;JOSEPH P. STEINER
分类号 C07D223/02;A61K8/00;A61K8/49;A61K31/401;A61K31/4025;A61K31/404;A61K31/41;A61K31/4178;A61K31/4192;A61K31/4196;A61K31/422;A61K31/4245;A61K31/427;A61K31/433;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4439;A61K31/445;A61K31/4525;A61K31/4535;A61K31/454;A61K31/55;A61P17/14;A61Q5/00;A61Q5/02;A61Q7/00;C07D207/12;C07D207/16;C07D211/60;C07D401/06;C07D403/04;C07D403/06;C07D405/06;C07D409/06;C07D417/06 主分类号 C07D223/02
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