摘要 |
PCT No. PCT/EP98/03284 Sec. 371 Date Dec. 1, 1999 Sec. 102(e) Date Dec. 1, 1999 PCT Filed Jun. 2, 1998 PCT Pub. No. WO98/55456 PCT Pub. Date Dec. 10, 1998The invention relates to a process for preparing chiral 3,4-dehydroproline compounds of formula (I), in which R, R' and R'' have the meanings given in the description. The invention is characterized by a pyrrolecarboxylic acid derivative compound of formula (II) reacted first with an alkali or alkaline earth metal in ammonia and then with an aqueous salt solution or a compound of formula (III) in which X is a leaving group to form the final chiral product compound. |