PREPARATION AND PURIFICATION OF A SALT OF ASPARTAME WITH ACESULFAM K

摘要

The invention relates to a process for the preparation of the salt of aspartame and acesulphamic acid wherein the salt of aspartame and acesulphamic acid is made available as a wet solid crystalline product which upon drying results in a product having a particle-size distribution in which at least 10 wt.% of the particles is larger than 200 mu m. This crystalline product has an improved stability as compared with the product of the state of the art. In one embodiment the wet solid crystalline product is also subjected, prior to the drying operation, to a washing operation with a basic aqueous solution having a pH of 8 or higher. The invention also relates to the salt of aspartame and acesulphamic acid having such an increased stability that the acetoacetamide content upon heating of that salt in dry form at a temperature of 80 DEG C for 48 hours remains lower than 10 ppm relative to the dry weight of the salt. In dried form, such salt of aspartame and acesulphamic acid has a particle-size distribution in which at least 10 wt.%, and more in particular at least 25 wt.%, of the particles is larger than 200 mu m.