| 摘要 |
<p>Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein a and b are 0-2, provided that the sum is 0-3; Q is (i) or (-N=); X is -O-, -S-, -SO-, -SO2-, -CH(OR8)-, -C(O)-, -C(R23)2-, optionally substituted alkenyl, alkynyl or (ii); R1 is optionally substituted aryl, heteroaryl, substituted amino, alkyl-OC(O)R8, aryloxyalkyl, (iii) wherein m is 1-4, or (iv) wherein d and e are 0-2; R?2, R3, R4 and R5¿ are H, alkyl, optionally substituted cycloalkyl, halogen, -OR?8, -N(R8)¿2, -CO2R8 or CF¿3?; R?6 and R7¿ are H, alkyl, alkenyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, cycloalkyl or cycloalkylalkyl, or R?6 and R7¿, form a 3-7-membered carbocyclic ring, or a 4-7-membered heterocyclic ring; R8 is H, alkyl, cycloalkyl, optionally substituted aryl or heteroaryl; R9 is alkyl, cycloalkyl, optionally substituted aryl or heteroaryl; R11 is H, alkyl or cycloalkyl; and R?23 is R8¿ or halogen; are claimed, as well as additional novel compounds; also claimed are pharmaceutical compositions and methods of using said novel compounds in the treatment of eating disorders and diabetes.</p> |
