发明名称 |
INHIBITORS OF HIV REVERSE TRANSCRIPTASE |
摘要 |
Disclosed are multibinding compounds which inhibit the enzyme HIV reverse transcriptase, an enzyme which catalyzes the conversion of viral RNA to single stranded DNA. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each multibinding compound comprises at least one nucleoside reverse transcriptase inhibitor and at least one non-nucleoside reverse transcriptase inhibitor. The multibinding compounds of this invention are useful to inhibit HIV reverse transcriptase in vivo, and accordingly to inhibit HIV replication in vivo.
|
申请公布号 |
CA2316999(A1) |
申请公布日期 |
1999.12.16 |
申请号 |
CA19992316999 |
申请日期 |
1999.06.08 |
申请人 |
ADVANCED MEDICINE, INC. |
发明人 |
AGGEN, JAMES;GRIFFIN, JOHN H.;MAMMEN, MATHAI;OARE, DAVID |
分类号 |
C07D499/44;A01N57/34;A61K31/00;A61K31/357;A61K31/397;A61K31/407;A61K31/421;A61K31/424;A61K31/431;A61K31/439;A61K31/444;A61K31/4545;A61K31/496;A61K31/522;A61K31/536;A61K31/5377;A61K31/546;A61K31/551;A61K31/65;A61K31/7028;A61K31/7034;A61K31/7036;A61K31/7042;A61K31/7048;A61K31/7052;A61K31/7056;A61K31/7064;A61K31/7068;A61K31/7072;A61K38/00;A61K39/00;A61K39/395;A61K39/44;A61K47/48;A61K51/00;A61P31/04;A61P31/18;A61P43/00;C07B61/00;C07C233/36;C07C233/78;C07C237/24;C07C237/26;C07C271/20;C07C275/42;C07C321/04;C07C323/12;C07C335/08;C07C335/32;C07D207/32;C07D207/333;C07D211/58;C07D215/56;C07D233/90;C07D235/30;C07D263/28;C07D265/18;C07D401/06;C07D401/12;C07D401/14;C07D405/04;C07D413/14;C07D453/02;C07D471/04;C07D471/14;C07D473/00;C07D473/34;C07D475/04;C07D475/08;C07D477/00;C07D487/04;C07D487/06;C07D493/04;C07D493/06;C07D495/04;C07D498/04;C07D498/18;C07D501/20;C07D519/00;C07H15/236;C07H15/238;C07H15/26;C07H17/08;C07H19/06;C07H19/20;C07K2/00;C07K4/00;C12N9/99;C12P19/38;C12Q1/26;C12Q1/44;C12Q1/48;C12Q1/533;C40B30/04;C40B40/04;G01N33/15;G01N33/50;G01N33/53;G01N33/543;G01N33/566;G01N33/573;G01N33/68;G01N33/92;G01N37/00;(IPC1-7):C07H19/073;A61K45/06;C07D411/14;C07H19/173;A61K31/513;A61K31/535;A61K31/557;A61K31/707 |
主分类号 |
C07D499/44 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|