| 摘要 |
<p>There is disclosed a method of identifying compounds having antidepressant activity which method comprises: a) contacting a cell expressing an alpha-1b-adrenergic receptor and transport-P protein with said compound to be tested; and b) prior to or after step a) contacting said compound with a cell expressing an alpha-1b-adrenergic receptor but not transport-P protein; and c) selecting a compound which preferentially binds transport P. Compounds identified using the method of the invention are also provided in addition to pharmaceutical compositions containing them and their use in treating depression.</p> |
