发明名称 |
POLY(ADP-RIBOSE) POLYMERASE GENE |
摘要 |
<p>The invention relates to poly(ADP-ribose)polymerase (PARP) homologues which are characterised by an amino acid sequence with a) a functional NAD+-binding site and b) no zinc-finger-sequence motif of general formula CX2CXmHX2C, wherein m is an integral number 28 or 30 and the radicals X represent any amino acid, independently of each other; and to the functional equivalents of said poly(ADP-ribose)polymerase (PARP) homologues. The invention also relates to nucleic acids coding the poly(ADP-ribose)polymerase (PARP) homologues, to antibodies with specificity for the novel protein, to pharmaceutical and gene therapy agents containing the inventive products, to methods for analytically determining the inventive proteins and nucleic acids, to methods for identifying the effectors or bonding partners of the inventive proteins, to novel PARP effectors and to methods for determining the effectiveness of effectors of this type.</p> |
申请公布号 |
CA2330206(A1) |
申请公布日期 |
1999.12.16 |
申请号 |
CA19992330206 |
申请日期 |
1999.06.04 |
申请人 |
BASF AKTIENGESELLSCHAFT |
发明人 |
HOGER, THOMAS;KOCK, MICHAEL;KROGER, BURKHARD;OTTERBACH, BERND;LUBISCH, WILFRIED;LEMAIRE, HANS-GEORG |
分类号 |
A01K67/027;A61K38/00;A61K38/45;A61K48/00;A61K49/00;A61P43/00;C07K14/455;C12N1/15;C12N1/19;C12N5/10;C12N9/10;C12N15/09;C12N15/54;C12Q1/68;G01N33/53;(IPC1-7):C12N9/10;C12N15/10;A61K31/70 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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