| 摘要 |
The present invention is directed to a method of inducing an anti-tumor response against a metastatic melanoma by administering an effective amount of a composition comprising at least one of the following: (i) a hapten-modified syngeneic mammalian melanoma cell substantially in a no growth phase, (ii) a hapten-modified melanoma cell membrane, (iii) a peptide isolated from said hapten-modified melanoma cell or membrane and (iv) a T cell capable of mediating an anti-tumor response such as for example regression of a melanoma. The metastatic melanoma treated according to the present invention includes metastatic melanoma which is limited to the lung and is preferably a small lung metastasis. The invention is further directed to a melanoma cell, an isolated melanoma cell membrane, a peptide isolated from such cell or membrane and a T cell having the property of inducing an anti-tumor response, a composition containing such cell, membrane, peptide, T cell or combination thereof, as well as the methods for theirisolation and preparation. |
