NOVEL THERAPEUTIC AGENTS THAT MODULATE ALPHA-1A ADRENERGIC RECEPTORS
摘要
Disclosed are novel multi-binding compounds (agents) which bind alpha-1A adrenergic receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the alpha-1A adrenergic receptor.
申请公布号
WO9964042(A1)
申请公布日期
1999.12.16
申请号
WO1999US12728
申请日期
1999.06.07
申请人
ADVANCED MEDICINE, INC.;GRIFFIN, JOHN, H.;MORAN, EDMUND, J.;THOMAS, G., ROGER
发明人
GRIFFIN, JOHN, H.;MORAN, EDMUND, J.;THOMAS, G., ROGER