发明名称 |
CINNAMOYL DISTAMYCIN ANALOGOUS DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS |
摘要 |
Compounds which are cinnamoyl distamycin derivatives of formula (I), wherein n is 2, 3 or 4; R0 is C1-C4 alkyl or C1-C3 haloalkyl; R1 and R2, which are the same or different, are selected from hydrogen, C1-C4 alkyl optionally substituted by one or more fluorine atoms; and C1-C4 alkoxy; X is a halogen atom; Y and Z are the same or different and are selected, independently for each heterocyclic ring of the polyheterocyclic chain, from N and CH; B is selected from: (a), (b), (c), (d), (e), (f), (g) and (h), wherein R3, R4, R5, R6 and R7 are, independently from each other, hydrogen or C1-C4 alkyl; or pharmaceutically acceptable salts thereof; provided that at least one of the heterocyclic rings within the polyheterocyclic chain is other than pyrrole; are useful as antitumor agents.
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申请公布号 |
WO9964413(A1) |
申请公布日期 |
1999.12.16 |
申请号 |
WO1999EP03595 |
申请日期 |
1999.05.22 |
申请人 |
PHARMACIA & UPJOHN S.P.A.;COZZI, PAOLO;BARALDI, PIER, GIOVANNI;BERIA, ITALO;CALDARELLI, MARINA;GERONI, MARIA, CRISTINA;PENNELLA, GIULIA;ROMAGNOLI, ROMEO |
发明人 |
COZZI, PAOLO;BARALDI, PIER, GIOVANNI;BERIA, ITALO;CALDARELLI, MARINA;GERONI, MARIA, CRISTINA;PENNELLA, GIULIA;ROMAGNOLI, ROMEO |
分类号 |
A61K31/4155;A61K31/4178;A61P35/00;C07D403/14;(IPC1-7):C07D403/14;A61K31/415 |
主分类号 |
A61K31/4155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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