发明名称 |
PREPARATION OF 19-NOR-VITAMIN D COMPOUNDS |
摘要 |
<p>A synthesis of 1 alpha -hydroxy-19-nor-vitamin D compounds comprises (a) the construction of a 5,8-diol-6-yne intermediate by joining ring-A and ring-C/D portions of the desired end product via the condensation of an acetylenic derivative containing the C/D-ring portion of the desired end product with a cyclic dihydroxy ketone representing the A-ring of the desired end product; (b) the partial reduction of the 6,7 acetylenic triple bond linkage between the A and C/D ring portions to obtain a 5,8-diol-6-ene intermediate; and (c) the reductive removal of the 5,8-oxygen functions to generate the required 5,7-diene end product from which the desired 7-trans(7E)-isomer is purified directly, or after optional double bond isomerization of the 7-cis(7Z)-isomer employing a novel thiophenol-promoted isomerization step.</p> |
申请公布号 |
KR100236252(B1) |
申请公布日期 |
1999.12.15 |
申请号 |
KR19930015241 |
申请日期 |
1993.08.06 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, HECTOR F.;SCHNOES, HEINRICH K.;ARIA, FARIBA |
分类号 |
C07C29/17;C07C35/17;C07C35/27;C07C401/00;C07F7/18;(IPC1-7):C07C401/00 |
主分类号 |
C07C29/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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