<p>The invention includes a chimeric virus for use in a vaccine preparation having a genome comprising nucleic acid sequences encoding at least one structural protein from one flavivirus and nucleic acid sequences encoding nonstructural protein from another flavivirus. The genome preferably includes mutations within the viral genome that reduce virus virulence and in a particularly preferred embodiment these vaccines are directed to flaviviruses such as dengue virus, tick-borne encephalitis virus and Japanese encephalitis virus.</p>
申请公布号
AT186744(T)
申请公布日期
1999.12.15
申请号
AT19920920708T
申请日期
1992.09.18
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
LAI, CHING-JUH;BRAY, MICHAEL;PLETNEV, ALEXANDER, G.;MEN, RUHE;CHANOCK, ROBERT, M.