发明名称 |
HERSTELLUNG VON CHIRALEN ALPHA- HALOGENCARBONSÄUREN |
摘要 |
<p>Prepn. of an optically active alpha -(chloro or bromo)-alkanoic acid, salt or deriv. of formula R(CH2)n-CH2-CHX-COOM (I) comprises enantiomer-selective hydrogenation of an alpha , beta -unsatd. alkenoic acid deriv. of formula (II) in presence of a ruthenium complex (III) of an optically active (pref. atropisomeric) diphosphine ligand. X = Cl or Br; M = H, N(R1)4<+>, alkali metal or alkaline earth metal cation; R1 = H or lower alkyl; n = 0 or 1; R = H or 1-20C alkyl (opt. terminally substd. by N(R2)2, COOR2, OR3, opt. protected CHO or opt. substd. ring); R2 = H or lower alkyl; R3 = H or protecting gp.</p> |
申请公布号 |
AT186718(T) |
申请公布日期 |
1999.12.15 |
申请号 |
AT19960109401T |
申请日期 |
1996.06.12 |
申请人 |
ROLIC AG |
发明人 |
BROGER, EMIL ALBIN;BUCHECKER, RICHARD;CRAMERI, YVO;LUKAC, TEODOR |
分类号 |
B01J31/24;C07B61/00;C07C51/36;C07C53/19;C07C55/32;C07C59/135;C07C59/147;C07C227/14;C07C229/20;C07F15/00;(IPC1-7):C07C53/19;C07C53/16 |
主分类号 |
B01J31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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