NOVEL PYRIDONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R<1> is -OH, a carboxy-protecting group or (alkyl)-amino group, R<2> is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R<3> is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R<4> is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R<5>, R<6> and R<7> are independently H, -NO2, halogen atom or lower alkyl group, R<8> is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R<12>, in which R<12> is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R<13>, in which R<13> is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.