发明名称 |
Tubulin promoter regulates gene expression in neurons |
摘要 |
The present invention relates to a DNA expression vector comprising a T alpha l alpha -tubulin promoter operatively linked upstream to a marker gene sequence relative to the direction of transcription in a eukaryotic expression vector adapted to be introduced into a mammal, or ancestor of the mammal at an embryonic stage and said promoter is controlling transcription of the marker gene. The present invention also relates to a method for testing material suspected of promoting neurogenesis and neuronal growth which comprises exposing a transgenic mammal according to the present invention said material and detecting said expressed marker gene as an indication of neurogenesis and neuronal growth.
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申请公布号 |
US6000772(A) |
申请公布日期 |
1999.12.14 |
申请号 |
US19970900026 |
申请日期 |
1997.07.24 |
申请人 |
MCGILL UNIVERSITY |
发明人 |
MILLER, FREDA DIANE;GLOSTER, ANDREW;CAUSING, CARRIE GRACE;TOMA, JEAN GEORGE |
分类号 |
A01K67/027;A61K48/00;A61P25/00;A61P25/28;C07H21/04;C12N5/00;C12N5/10;C12N15/00;C12N15/09;C12N15/85;C12Q1/02;C12Q1/68;(IPC1-7):C12Q1/02 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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