发明名称 |
Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor |
摘要 |
A method for stimulating chondrocyte proliferation and inhibiting chondrocyte differentiation along the endochondral developmental pathway is provided comprising contacting condrocytes with an effective amount of Platelet-Derived Growth Factor (PDGF) such as PDGF-BB, PDGF-AA OR PDGF-AB in the substantial absence of growth factors which promote cell differentiation. This allows such cells to be multiplied in culture for loading onto a scaffolding material and implanting into a cartilage or bone wound.
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申请公布号 |
US6001352(A) |
申请公布日期 |
1999.12.14 |
申请号 |
US19970829308 |
申请日期 |
1997.03.31 |
申请人 |
OSTEOBIOLOGICS, INC. |
发明人 |
BOYAN, BARBARA D.;SCHWARTZ, ZVI |
分类号 |
A61K35/12;C12N5/077;(IPC1-7):A61K35/32;C12N11/08;C12N5/00;C12N5/08 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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