Treatment or prophylaxis of diseases caused by pilus-forming bacteria
摘要
Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.
申请公布号
US6001823(A)
申请公布日期
1999.12.14
申请号
US19950462436
申请日期
1995.06.05
申请人
HULTGREN, SCOTT;KUEHN, META;XU, ZHENG;OGG, DEREK;HARRIS, MARK;LEPISTOE, MATTI;KIHLBERG, JAN;JONES, CHARLES HAL
发明人
HULTGREN, SCOTT;KUEHN, META;XU, ZHENG;OGG, DEREK;HARRIS, MARK;LEPISTOE, MATTI;KIHLBERG, JAN;JONES, CHARLES HAL