| 摘要 |
Disclosed are molecules having one specificity for CD40 and the other for a tumor cell antigen. The molecules may be bispecific, or multispecific, antibodies. The molecules are useful for treating cancer and tumors. Where the tumor cell specificity is directed against a tumor cell surface antigen of sufficient density, upon in vivo administration, a number of bispecific molecules will bind to the tumor cell surface and present, in sum, multivalency for the CD40-expressing cells. The multivalent anti-CD40 can now ligate CD40 on adjacent CD40-expressing cells (e.g., macrophages, dendritic cells, B-lymphocytes, and others), resulting in activation of these CD40 cells, which aid in eliminating the tumor. |
