ANTHRAPYRAZOLONE DERIVATIVES, METHODS OF THEIR SYNTHESIS AND METHODS OF SYNTHESIS OF ANTHRAPYRAZOLONES FROM THEIR SHOWING ANTITUMOR ACTIVITY

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds involving 5-chloro- -2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[(2,4,6-trimethyl-phenyl)methoxy] anthra[1,9-cd] pyrazole-6(2H)-one and its analogs of the formula (I) <EMI ID=0.388 HE=30 WI=42 TI=CHI> that are used as intermediate compounds for the synthesis of anthrapyrazolones showing an antitumor activity and among them - lozoxanthrone. Invention relates to also methods of synthesis and isolation of compounds of the formula (I) and methods of synthesis of antitumor derivatives of anthrapyrazolone (involving lozoxathrone). EFFECT: broadened arsenal of antitumor agents. 25 cl, 5 dwg, 12 ex