发明名称 |
STABILIZERS FOR LYOPHILIZED VACCINES |
摘要 |
Vaccine stabilizers, vaccine formulations and lyophilized vaccines with enhanced thermostability are disclosed. The vaccine formulations comprise an increased amount of a 6-carbon polyhydric alcohol (such as sorbitol), an increase amount of a disaccharide (such as sucrose) and an amount of a physiologically active buffer to adjust the pH from about 6.0 to about 7.0.< /SDOAB> |
申请公布号 |
CA2333505(A1) |
申请公布日期 |
1999.12.09 |
申请号 |
CA19992333505 |
申请日期 |
1999.05.28 |
申请人 |
MERCK & CO. |
发明人 |
VOLKIN, DAVID B.;SHEU, SU-PI;BURKE, CARL J. |
分类号 |
C12N7/00;A61K9/00;A61K9/19;A61K39/00;A61K39/12;A61K39/13;A61K39/165;A61K39/20;A61K39/245;A61K39/25;A61K39/29;A61K39/295;A61K47/00;A61K47/02;A61K47/10;A61K47/12;A61K47/26;A61K47/42;A61P31/12;(IPC1-7):A61K9/19;A61K31/045;C07H3/04 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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