发明名称 |
TUMOR ANTIGEN USEFUL IN DIAGNOSIS AND THERAPY OF PROSTATE AND COLON CANCER |
摘要 |
Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell surface serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labelled with a detectable marker or toxin or therapeutic composition. Several monoclonal antibodies specifically reactive with 20P1F12/TMPRSS2 are also described herein.
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申请公布号 |
CA2329137(A1) |
申请公布日期 |
1999.12.09 |
申请号 |
CA19992329137 |
申请日期 |
1999.06.01 |
申请人 |
UROGENESYS, INC. |
发明人 |
SAFFRAN, DOUGLAS C.;AFAR, DANIEL E.;RAITANO, ARTHUR B.;HUBERT, RENE S.;MITCHELL, STEPHEN CHAPPELL;LEONG, KAHAN |
分类号 |
G01N33/50;A61K38/00;A61K39/395;A61P13/08;A61P35/00;C07K14/47;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/09;C12P21/08;C12Q1/68;G01N33/566;G01N33/574;(IPC1-7):C12N9/64;C12N15/57 |
主分类号 |
G01N33/50 |
代理机构 |
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主权项 |
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地址 |
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