发明名称 |
PREPARATION OF CARBOXYLIC COMPOUNDS AND THEIR DERIVATIVES |
摘要 |
The application relates to a process which comprises: A) forming a reaction product composition comprising arylcarboxylic acid or substituted arylcarboxylic acid in a polar organic solvent medium by palladium-catalyzed hydrocarboxylation of an arylolefin or substituted arylolefin in a liquid medium comprising polar organic solvent, water, HCl, and at least one ether; B) mixing with said reaction product composition an aqueous solution of inorganic base to form a mixture comprising an aqueous phase containing dissolved inorganic salt of said arylcarboxylic acid or substituted arylcarboxylic, and before and/or during and/or after such mixing, distilling a substantial portion of the ether from the reaction mixture, such that a mixture of residual organic phase and such aqueous phase remain as a distillation residue; C) separating the phases from each other; D) distilling residual organic impurities from the aqueous phase and providing an aqueous solution having a concentration in the range of 10 and 35 wt%, by, if necessary, adjusting the concentration of such aqueous solution by removal therefrom or addition thereto of water; E) washing the aqueous solution with non-polar organic solvent at least twice; F) mixing non-oxidizing mineral acid with the aqueous phase in the presence of non-polar liquid solvent to form (i) an organic phase composed of a solution of arylcarboxylic acid or substituted arylcarboxylic acid in non-polar liquid organic solvent and (ii) an aqueous phase; G) separating the phases from each other; and H) crystallizing arylcarboxylic acid or substituted arylcarboxylic acid from organic solvent. |
申请公布号 |
EP0961765(A2) |
申请公布日期 |
1999.12.08 |
申请号 |
EP19980902424 |
申请日期 |
1998.01.08 |
申请人 |
ALBEMARLE CORPORATION |
发明人 |
LIN, RONNY, W.;HERNDON, R., CARL, JR.;ALLEN, ROBERT, H.;CHOCKALINGHAM, KANNAPPAN, C.;FOCHT, GARY, D.;ROY, RANJIT, K. |
分类号 |
B01J31/24;C07B37/04;C07B61/00;C07C2/86;C07C15/40;C07C41/30;C07C51/14;C07C51/41;C07C51/42;C07C51/487;C07C59/64;C07C67/38;C07C209/12;C07C211/62;(IPC1-7):C07C51/00 |
主分类号 |
B01J31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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