发明名称 |
ANTISENSE OLIGONUCLEOTIDE MODULATION OF HUMAN THYMIDYLATE SYNTHASE EXPRESSION |
摘要 |
Compounds, compositions and methods are provided for modulating the expression of human thymidylate synthase. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding thymidylate synthase. Methods of using these oligonucleotides for modulation of thymidylate synthase expression and for treatment of diseases such as cancers believed to be responsive to modulation of thymidylate synthase expression are provided.
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申请公布号 |
WO9963114(A1) |
申请公布日期 |
1999.12.09 |
申请号 |
WO1999US12080 |
申请日期 |
1999.06.01 |
申请人 |
ISIS PHARMACEUTICALS, INC.;DEAN, NICHOLAS |
发明人 |
DEAN, NICHOLAS |
分类号 |
A61K38/00;A61K45/06;C12N15/113;(IPC1-7):C12Q1/68;C12H21/04;C12N15/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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