发明名称 |
Piperidones as tachykinin antagonists |
摘要 |
<p>The present invention relates to a compound of the formula:- <CHEM> or a pharmaceutically acceptable acid addition salt or solvate thereof, wherein R is C3-C7 cycloalkyl, (C3-C7 cycloalkyl)C1-C4 alkylene or benzyl; R<1> is phenyl optionally substituted by 1 or 2 substituents each independently selected from fluoro and chloro; X is O or NSO2R<2>; and R<2> is C1-C4 alkyl or halo(C1-C4)alkyl, together with processes for the preparation of, intermediates used in the preparation of, compositions containing and uses of, such compounds having tachykinin antagonist activity.</p> |
申请公布号 |
EP0962457(A1) |
申请公布日期 |
1999.12.08 |
申请号 |
EP19990304238 |
申请日期 |
1999.06.01 |
申请人 |
PFIZER LIMITED;PFIZER INC. |
发明人 |
FOX, DAVID NATHAN ABRAHAM;MATHIAS, JOHN PAUL;TOMMASINI, IVAN |
分类号 |
A61K31/00;A61K31/4427;A61K31/443;A61K31/445;A61K31/4465;A61K31/4523;A61K31/453;A61K31/495;A61K31/496;A61K31/535;A61K31/5375;A61K31/5377;A61P1/00;A61P11/00;A61P11/06;A61P13/00;A61P17/00;A61P19/00;A61P19/02;A61P25/00;A61P25/02;A61P25/04;A61P25/22;A61P25/24;A61P25/28;A61P37/00;A61P37/08;A61P43/00;C07D401/06;C07D401/14;C07D405/14;C07D407/14;(IPC1-7):C07D401/14;C07D405/04;C07D401/04 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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