| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new TSC501 gene having a specific amino acid sequence, containing a base sequence encoding proteins having acetyl transferase activity, capable of expression in kidney and liver-specific manner, and useful as a medicament metabolism promoter or the like. SOLUTION: This new TSC501 gene is such one as to contain a base sequence encoding either a protein having an amino acid sequence of the formula or a protein having an amino acid sequence wherein one or more amino acids are deleted, substituted or added in the amino acid sequence of the formula and also having acetyl transferase activity, be capable of expression in kidney- and liver-specific manner, and related to medicament metabolism, therefore being useful as a medicament metabolism promoter or the like. This gene is obtained by screening a human normal kidney cDNA library constructed by conventional method using human normal kidney cDNA, using, as probe, a cDNA fragment consisting of a labeled partial sequence thereof. |
