Agonist antibodies against the flk2/flt3 receptor and uses thereof
摘要
Agonist antibodies are disclosed which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain thereof. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells for example. The antibodies are able to cause primitive hematopoietic cells to proliferate and/or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, for example.
申请公布号
US5997865(A)
申请公布日期
1999.12.07
申请号
US19950434878
申请日期
1995.05.04
申请人
BENNETT, BRIAN D.;BROZ, SUSAN D.;MATTHEWS, WILLIAM;ZEIGLER, FRANCIS C.
发明人
BENNETT, BRIAN D.;BROZ, SUSAN D.;MATTHEWS, WILLIAM;ZEIGLER, FRANCIS C.