| 摘要 |
The present invention is directed to reduce elevated levels of tumor necrosis factor-alpha (TNF- alpha ) found in a failing heart. The present invention is directed to a composition and method of regulating TNF- alpha expression in myocardial tissue by treating the myocardial tissue with biological equivalents of endogenous adenosine. A composition and method of using the composition to treat patients with damaged myocardial tissue is provided which increases the cellular availability of adenosine with a resulting decrease of TNF- alpha levels in the heart. The present invention provides a novel pharmacological intervention program in failing mammalian hearts, and more particularly provides a cardioprotective treatment to patients with congestive heart failure.
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