| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject collagen useful for e.g. biocompatible materials by culturing recombinant host cells containing a DNA encoding a fibrillar collagen monomer devoid of C propeptide SSAD under conditions appropriate for expressing the DNA. SOLUTION: This fibrillar collagen is obtained, without the need of any after-treatment, by culturing recombinant host cells such as yeast cells transferred with a recombinant DNA including a DNA encoding a fibrillar collagen monomer devoid of at least 50% of C propeptide SSAD under conditions appropriate for expressing the DNA. This fibrillar collagen is useful as e.g. a component of biocompatible materials for use in base materials for in vitro cell culture in the biological investigation, artificial organ implants, sustained medicament release matrices, artificial skin, bandage matrices for wounds and therapeutic matrices for wounds. |
