4-Oxa and 4-thia steroids

摘要

PCT No. PCT/US96/16883 Sec. 371 Date Apr. 23, 1998 Sec. 102(e) Date Apr. 23, 1998 PCT Filed Oct. 22, 1996 PCT Pub. No. WO97/15564 PCT Pub. Date May 1, 1997The compounds of the present invention are those of structural formula (I) wherein X is oxygen or sulfur. Pharmaceutical compositions and methods of use of the compounds in the treatment of hyperandrogenic conditions are disclosed. In addition, the combination of the compounds with other active agents such as finasteride, minoxidil and retinoic acid or a derivative thereof is disclosed.