发明名称 |
METHODS OF CANCER DIAGNOSIS USING A CHIMERIC TOXIN |
摘要 |
The present invention relates to methods for cancer diagnosis using a chimeric toxin. In particular, the invention relates to the use of a chimeric toxin composed of gonadotropin releasing hormone (GnRH) and Pseudomonas exotoxin A (PE) to detect a tumor-associated epitope expressed by human adenocarcinomas. Mutated GnRH-PE molecules that bind but do not kill tumor cells are exemplified. |
申请公布号 |
WO9949059(A3) |
申请公布日期 |
1999.12.02 |
申请号 |
WO1999IL00166 |
申请日期 |
1999.03.24 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW |
发明人 |
LORBERBOUM-GALSKI, HAYA;BEN-YEHUDAH, AMI;NECHUSHTAN, AMOTZ;YARKONI, SHAI;MARIANOVSKY, IRINA |
分类号 |
C07K7/23;C07K14/21;G01N33/574 |
主分类号 |
C07K7/23 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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