HYDROXAMIC ACID DERIVATIVE AND PHARMACEUTICAL USE THEREOF

摘要

Hydroxamic acid derivatives represented by general formula (I) or pharmacologically acceptable salts thereof; medicinal compositions containin g the same and medicinal utilization thereof wherein each symbol has the meani ng as defined in the specification. Because of having TNF-.alpha. production inhibitory effect, these derivatives or pharmacologically acceptable salts thereof are useful in preventing/treating autoimmune diseases and inflammato ry diseases, for example, sepsis, MOF, rheumatoid arthritis, Crohn's disease, cachexia, myasthenia gravis, systemic lupus erythematosus, asthma, I type diabetes and psoriasis.