发明名称 |
NOVEL NUCLEOSIDES HAVING BICYCLIC SUGAR MOIETY |
摘要 |
Conformationally restricted 2',4'-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2' and C4' of nucleosides through a linker or linking molecule. These novel nucleosides have a desired, locked sugar pucker and are potentially useful as pharmaceutical ingredients. Oligonucleotides composed of these novel nucleosides are useful for oligonucleotide therapeutic and diagnostic compounds.
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申请公布号 |
WO9960855(A1) |
申请公布日期 |
1999.12.02 |
申请号 |
WO1999US11442 |
申请日期 |
1999.05.24 |
申请人 |
ICN PHARMACEUTICALS, INC.;WANG, GUANGYI |
发明人 |
WANG, GUANGYI |
分类号 |
A61P31/00;C07G3/00;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H21/00;(IPC1-7):A01N43/04;C07H1/00;C07H19/00 |
主分类号 |
A61P31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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