发明名称 |
A STABLE ORAL PHARMACEUTICAL COMPOSITION CONTAINING A SUBSTITUTED PYRIDYLSULFINYL BENZIMIDAZOLE |
摘要 |
A pharmaceutical composition which is stable and suitable for oral administration to a patient comprises a mixture of a substituted pyridyl sulfinyl benzimidazole having gastric acid secretion inhibitory activity (such as omeprazole, lansoprazole, or pantoprazole), and a pharmaceutically acceptable carrier. The carrier comprises a polymer having vinyl pyrrolidone monomeric units, such as polyvinylpyrrolidone or a vinyl pyrrolidone-vinyl acetate copolymer. Surprisingly, it has been found that the vinylpyrrolidone polymer acts as a stabilizing excipient on the substituted pyridyl sulfinyl benzimidazole so that the composition need not include any alkaline components to prevent degradation of the active ingredient. In a preferred embodiment, the composition is in the form of a capsule, whereby the mixture of the substituted pyridyl sulfinyl benzimidazole and the vinyl pyrrolidone polymer in the form of a powder blend or granules, is contained within a capsule shell, which capsule shell is made from an enteric material or is coated with an enteric material.
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申请公布号 |
WO9961022(A1) |
申请公布日期 |
1999.12.02 |
申请号 |
WO1999IB00139 |
申请日期 |
1999.01.26 |
申请人 |
RANBAXY LABORATORIES LIMITED;THACHARODI, DILIPKUMAR;RAMPAL, ASHOK |
发明人 |
THACHARODI, DILIPKUMAR;RAMPAL, ASHOK |
分类号 |
A61K9/14;A61K9/48;A61K31/4439;(IPC1-7):A61K31/44;A61K47/32 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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