THERAPEUTIC APPLICATIONS OF MATURE FLINT (MFLINT) POLYPEPTIDES OR OPG3, A MEMBER OF THE TNF RECEPTOR SUPERFAMILY,申请号WO1999US06797-传众专利搜索

发明名称	THERAPEUTIC APPLICATIONS OF MATURE FLINT (MFLINT) POLYPEPTIDES OR OPG3, A MEMBER OF THE TNF RECEPTOR SUPERFAMILY
摘要	Mature FLINT protein (mFLINT) binds FasL and LIGHT, and prevents FasL-Fas interaction. mFLINT inhibits FasL-Fas-mediated apoptotic and proinflammatory activity, and is useful in treating disorders associated with abnormal apoptosis and inflammation. The invention provides the amino acid and nucleotide sequences of FLINT and mature FLINT. The preparation and characterization of transgenic animals that express FLINT is disclosed. Therapeutic compositions and methods of treatment utilizing mFLINT are also provided.
申请公布号	WO9950413(A3)	申请公布日期	1999.12.02
申请号	WO1999US06797	申请日期	1999.03.30
申请人	ELI LILLY AND COMPANY;BUMOL, THOMAS, FRANK;DOU, SHENSHEN;GLASEBROOK, ANDREW, LAWRENCE;GOULD, KENNETH, ELLIOT;HALE, JOHN, EDWARD;HEUER, JOSEF, GEORG;HUI, KWAN, YUK;KHARITONENKOV, ALEXEI;MIZRAHI, JACQUES;NA, SONGQING;NOBLITT, TIMOTHY, WAYNE;REIDY, CHARLES, ARTHUR;SONG, HO, YEONG;WANG, JIAN;WU, XIYING;ZUCKERMAN, STEVEN, HAROLD	发明人	BUMOL, THOMAS, FRANK;DOU, SHENSHEN;GLASEBROOK, ANDREW, LAWRENCE;GOULD, KENNETH, ELLIOT;HALE, JOHN, EDWARD;HEUER, JOSEF, GEORG;HUI, KWAN, YUK;KHARITONENKOV, ALEXEI;MIZRAHI, JACQUES;NA, SONGQING;NOBLITT, TIMOTHY, WAYNE;REIDY, CHARLES, ARTHUR;SONG, HO, YEONG;WANG, JIAN;WU, XIYING;ZUCKERMAN, STEVEN, HAROLD
分类号	A01K67/027;A61K35/00;A61K38/00;A61K38/17;A61P1/16;A61P3/10;A61P7/00;A61P7/02;A61P9/10;A61P35/00;A61P43/00;C07K14/705;C12N15/09;C12N15/12;C12P21/02;C12R1/19	主分类号	A01K67/027
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