发明名称 |
IL-12 ENHANCEMENT OF IMMUNE RESPONSES TO T-INDEPENDENT ANTIGENS |
摘要 |
The present invention relates to a method of modulating an immune response to a T-cell or thymus independent antigen in a host (e.g., mammalian, including human), comprising administering to the host an effective amount of interleukin-12 (IL-12) and the T-cell independent antigen. In one embodiment, the present invention relates to a method of inducing an immune response to a TI antigen in a host (e.g., mammalian, including human), which comprises administering to the host an effective amount of interleukin-12 (IL-12) and the TI antigen. In another embodiment, the present invention relates to a method of enhancing an immune response against a TI antigen in a host, which comprises administering to the host an effective amount of IL-12 and the TI antigen. The methods of the present invention can be used, for example, to induce and or enhance a humoral immune response (IgG2a and/or IgG3 humoral immune response). |
申请公布号 |
WO9944636(A3) |
申请公布日期 |
1999.12.02 |
申请号 |
WO1999US04679 |
申请日期 |
1999.03.04 |
申请人 |
THE MEDICAL COLLEGE OF OHIO;METZGER, DENNIS, W.;BUCHANAN, RENEE, M. |
发明人 |
METZGER, DENNIS, W.;BUCHANAN, RENEE, M. |
分类号 |
A61K38/00;A61K39/00;A61K39/002;A61K39/095;A61K39/102;A61K39/12;A61K39/39;A61P37/04;A61P43/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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