发明名称 PHENYLALANINE DERIVATIVES HAVING VLA-4 ANTAGONISTIC ACTIVITY
摘要 Phenylalanine derivatives of formula (1) are described, wherein R is a carboxylic acid or a derivative thereof; L<1> is a linker atom or group; and R<5> is a group -L<2>(CH2)tR<6> in which L<2> is a -N(R<7>)CO- or -N(R<7>)CS- group. The compounds are able to inhibit the binding alpha 4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
申请公布号 WO9961465(A1) 申请公布日期 1999.12.02
申请号 WO1999GB01615 申请日期 1999.05.21
申请人 CELLTECH THERAPEUTICS LIMITED;HEAD, JOHN, CLIFFORD;ARCHIBALD, SARAH, CATHERINE;WARRELLOW, GRAHAM, JOHN;PORTER, JOHN, ROBERT 发明人 HEAD, JOHN, CLIFFORD;ARCHIBALD, SARAH, CATHERINE;WARRELLOW, GRAHAM, JOHN;PORTER, JOHN, ROBERT
分类号 A61K31/425;A61K38/00;A61P29/00;C07D213/82;C07K5/078;(IPC1-7):C07K5/078;A61K38/05 主分类号 A61K31/425
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