发明名称 |
CONJUGATE VACCINES FOR THE PREVENTION OF DENTAL CARIES |
摘要 |
The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan or to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutants streptococcus. |
申请公布号 |
WO9952548(A3) |
申请公布日期 |
1999.12.02 |
申请号 |
WO1999US07828 |
申请日期 |
1999.04.09 |
申请人 |
LEES, ANDREW;TAUBMAN, MARTIN, A.;SMITH, DANIEL, J. |
发明人 |
LEES, ANDREW;TAUBMAN, MARTIN, A.;SMITH, DANIEL, J. |
分类号 |
C12N15/09;A61K31/716;A61K38/45;A61K39/09;A61K39/39;A61P1/02;A61P37/04;C07K14/315;C07K14/33;C12N9/10;C12N15/54 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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