发明名称 |
THE INDUCTION OF ANTIOBIOTIC PROTEINS AND PEPTIDES BY LAIT/sCD14-PROTEIN |
摘要 |
A method of ameliorating the symptoms of sepsis comprising directly exposing epithelial cells of a mammal in need thereof to soluble CD14, or active variants thereof. A method of obtaining CD14 from a stock solution containing protein of a mammary secretion is described. A method of directly activating B cells using a soluble polypeptide having the amino acid sequence selected from the group consisting of leu-leu-leu-leu-leu-leu-pro-ser, leu-leu-leu-leu-leu-leu-pro-leu; and leu-leu-leu-leu-leu-leu-val-his, and which is specifically recognized by the monoclonal antibody 3C10 and which activates B cells is described. Bovine CD14 genomic DNA is described. |
申请公布号 |
WO9961468(A2) |
申请公布日期 |
1999.12.02 |
申请号 |
WO1999CA00482 |
申请日期 |
1999.05.27 |
申请人 |
GEMMA BIOTECHNOLOGY LTD.;JULIUS, MICHAEL, H.;FILIPP, DOMINIK |
发明人 |
JULIUS, MICHAEL, H.;FILIPP, DOMINIK |
分类号 |
A01K67/027;A23L1/305;A61K35/20;A61K38/00;A61K45/00;A61P31/04;A61P43/00;C07K14/705;C07K16/28;C12N5/10;C12N15/09;C12P21/08;G01N33/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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