发明名称 PYRIMIDIN-AMINOMETHYL-PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE CONTROL OF HELICOBACTER BACTERIA
摘要 <p>Compounds of formula (I) in which R1, R2 and R3 are hydrogen, 1-4C-alkyl or halogen, R4, R5, R6 and R9 are hydrogen or 1-4C-alkyl, R7 and R8 are hydrogen, 1-4C-alkyl, 1-4C-alkoxy or halogen, A is 1-7C-alkylene, 2-7C-alkenylene, 3-7C-cycloalkylene or phenylene, G is hydrogen, hydroxyl, 1-7C-alkyl, 1-4C-alkyl which is completely or mainly substituted by fluorine, 2-7C-alkenyl, 3-7C-cycloalkyl, a mono- or di-1-4C-alkylcarbamoyl or -thiocarbamoyl radical, an N-1-4C-alkyl-N'-cyanoamidino radical, a 1-N-1-4C-alkylamino-2-nitroethylene radical, an N-2-propynyl-N'-cyanoamidino radical, an aminosulfonylamidino radical, the radical -N(R10)R11, the part of the compound of formula (I) bonded to A (including X and via X), the glucopyranoside radical or a cyclic system or bicyclic system which is unsubstituted or substituted by R12 and R13 and which is selected from the group consisting of benzene, napththalene, furan, thiophene, pyrrole, oxazole, oxazoline, oxazolidinone, isoxazole, thiazole, thiazoline, isothiazole, imidazole, imidazoline, pyrazole, triazole, tetrazole, thiadiazole, thiadiazole 1-oxide, oxadiazole, pyridine, pyridine N-oxide, pyrimidine, halopyrimidine, piperidine, triazine, pyridone, benzimidazole, imidazopyridine, benzothiazole, benzoxazole, quinoline and imidazopyridazine, X is O (oxygen), N-1-4C-alkyl, NH or S, Y is O (oxygen), N-1-4C-alkyl, NH, S 1,4-piperazinylene or 1,4-piperidinylene, Z is O (oxygen), N-1-4C-alkyl, NH or S or CO, m is a number from 1 to 7, n is a number from 0 to 4, t is the number 0, 1 or 2 and u is the number 0 or 1, and their salts, are suitable for the control of Helicobacter bacteria.</p>
申请公布号 WO1999061439(A1) 申请公布日期 1999.12.02
申请号 EP1999003477 申请日期 1999.05.20
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