摘要 |
Compounds represented by general formula (1) which are useful as remedies an d preventives for diseases caused by acceleration in the sodium/proton exchang e system, wherein R1, R2, R3, R4 and R5 represent each hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, a saturated aromatic ring, acyl, etc.; Y1, Y2, Y3 and Y4 represent each a single bond, - CH2-, -O-, -CO-, etc., provided that at least two of Y1 to Y4 represent each a group other than a single bond; and Z may be absent or one or more Zs may be present and each represents alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, a saturated aromatic ring, halogeno, carboxy, alkoxycarbonyl, an aromatic group, acyl, etc.
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