发明名称 |
Anti-fibrotic medicament |
摘要 |
Compounds of submicromolar concentrations of a histone deacetylase inhibitor, useful as anti-fibrotic agents. The compounds strongly inhibit three main features of myofibroblastic differentiation of cultured hepatic stellate cells and of skin fibroblasts: (1) synthesis of collagens type I and III, the predominant collagens in fibrosis of liver and other organs; (2) cellular proliferation; and (3) expression of smooth muscle alpha -actin, a marker for activated myofibroblasts. Preferred compounds include trichostatin A or a pharmaceutically acceptable salt thereof, and sodium butyrate.
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申请公布号 |
US5993845(A) |
申请公布日期 |
1999.11.30 |
申请号 |
US19970922338 |
申请日期 |
1997.09.03 |
申请人 |
VRIJE UNIVERSITEIT BRUSSEL |
发明人 |
GEERTS, ALBERT EMMANUEL CORNEILLE;NIKI, TOSHIRO |
分类号 |
A61K9/06;A61K31/165;A61K31/19;A61K38/12;A61K45/00;A61P1/16;A61P17/00;A61P43/00;(IPC1-7):A61F2/02 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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