GENETICALLY ENGINEERED ANTIBODIES.

摘要

PCT No. PCT/EP93/00505 Sec. 371 Date Sep. 14, 1994 Sec. 102(e) Date Sep. 14, 1994 PCT Filed Mar. 5, 1993 PCT Pub. No. WO93/19180 PCT Pub. Date Sep. 30, 1993The invention concerns antiidiotypic antibodies comprising human constant regions, and murine variable regions bearing the internal image of human high molecular weight-melanoma associated antigen which have the specificity of said antibody. These antiidiotypic monoclonal antibodies have immune-regulatory functions and can therefore be used for diagnostic and therapeutic purposes, such as the treatment of melanoma.