| 发明名称 |
Oncoprotein protein kinase |
| 摘要 |
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
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| 申请公布号 |
US5994513(A) |
申请公布日期 |
1999.11.30 |
| 申请号 |
US19980150200 |
申请日期 |
1998.09.08 |
| 申请人 |
UNIVERSITY OF CALIFORNIA |
发明人 |
KARIN, MICHAEL;LIN, ANNING |
| 分类号 |
G01N33/573;A61K31/00;A61K38/00;A61K39/395;A61P5/40;A61P9/08;A61P9/10;A61P25/04;A61P29/00;A61P31/00;A61P31/12;A61P35/00;A61P35/02;A61P37/00;A61P37/02;A61P43/00;C07H21/04;C07K14/705;C07K14/82;C07K16/30;C07K16/32;C07K16/40;C12N5/10;C12N9/12;C12N15/02;C12N15/09;C12N15/54;C12P21/08;C12Q1/68;G01N33/574;G01N33/577;(IPC1-7):C07K16/40 |
主分类号 |
G01N33/573 |
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