We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.
申请公布号
US5994313(A)
申请公布日期
1999.11.30
申请号
US19950483898
申请日期
1995.06.07
申请人
BOARD OF TRUSTEES OF THE LELAND S. STANFORD, JR. UNIV.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人
CRABTREE, GERALD R.;SCHREIBER, STUART L.;SPENCER, DAVID M.;WANDLESS, THOMAS J.;BELSHAW, PETER