| 摘要 |
PCT No. PCT/GB96/00863 Sec. 371 Date Dec. 11, 1997 Sec. 102(e) Date Dec. 11, 1997 PCT Filed Apr. 4, 1996 PCT Pub. No. WO96/31551 PCT Pub. Date Oct. 10, 1996A microgel is produced by a two-stage process wherein the monomers are first polymerized in the absence of solvent for a controlled period, and in a second stage solvent is added and polymerization is completed. The polymer is preferably a polyurethane formed from a polyalkylene glycol, a triol and a diisocyanate. The molecular weight is typically 100,000 to 200,000. The microgels form granules which may be compressed into solid form. Such solid forms containing an active agent, such as a protein, are useful as sustained delivery devices.
|
