Capillary electrophoresis of transferrin glycoforms
摘要
A capillary electrophoresis method for resolving transferrin glycoforms in a sample is described. The capillary comprises a lumen, an inlet and an outlet. The lumenal surface of the capillary is charge-neutral and the capillary contains a buffer containing a polymeric matrix. The transferrin sample is contacted with the inlet of the capillary. A voltage is applied to the capillary such that the inlet is a cathode and the outlet is an anode and such that the voltage is effective for resolving transferrin glycoforms. A method for diagnosing chronic alcoholism or carbohydrate-deficient glycoprotein syndrome using CE to resolve abnormal populations of transferrin glycoforms is also described.
申请公布号
US5993626(A)
申请公布日期
1999.11.30
申请号
US19970788323
申请日期
1997.01.24
申请人
LANDERS, JAMES P.;PRASAD, RAJANI;ODA, ROBERT P.;STOUT, ROBERT L.
发明人
LANDERS, JAMES P.;PRASAD, RAJANI;ODA, ROBERT P.;STOUT, ROBERT L.