Vitamin D response element binding protein

摘要

The invention relates to the discovery and purification of novel vitamin D response element binding proteins and the isolation of polynucleotide sequences encoding the proteins. Vitamin D response element binding proteins are distinct from the vitamin D receptor. Vitamin D response element binding proteins can interfere with the biological activity of the vitamin D receptor and other related intracellular receptor proteins. One aspect of the invention is to provide purified vitamin D response element binding proteins. Another aspect of the invention is to provide polynucleotides encoding the vitamin D response element binding proteins of the invention and to provide polynucleotides complementary to polynucleotide coding strand. Another aspect of the invention is to provide antibodies capable of binding to the vitamin D response element binding proteins of the invention. Another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between vitamin D response element binding protein and vitamin D response elements.