| 摘要 |
Compositions and methods are disclosed for improving the effectiveness of a chemotherapeutic regimen to eradicate multidrug-resistant transformed cells from the body of a mammal, preferably from the body of a human. The present disclosure capitalizes on the discovery of a novel multidrug-resistance associated protein (MRP), herein designated MRP- beta . The disclosed compositions include MRP- alpha nucleic acids, including probes and antisense oligonucleotides, MRP- beta polypeptides and antibodies, MRP- beta expressing host cells, and non-human mammals transgenic or nullizygous for MRP- beta . The disclosed methods include methods for attenuating aberrant MRP- beta gene expression, protein production and/or protein function. In addition, methods are disclosed for identifying and using a modulator, such as an inhibitor, of MRP- beta . Preferably, the modulator is a small molecule.
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