发明名称 |
Water soluble texaphyrin metal complex preparation |
摘要 |
The present invention is directed to methods for synthesizing water soluble hydroxy-substituted texaphyrins retaining lipophilicity. The synthesis comprises condensing a diformyltripyrrole with an ortho-phenylenediamine to give a nonaromatic texaphyrin having at least one hydroxy substituent, and oxidizing the condensation product to form an aromatic texaphyrin metal complex having at least one hydroxy substituent. These expanded porphyrin-like macrocycles may be used for magnetic resonance imaging and for photodynamic therapy in the treatment of atheroma and tumors.
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申请公布号 |
US5994535(A) |
申请公布日期 |
1999.11.30 |
申请号 |
US19980031239 |
申请日期 |
1998.02.26 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SESSLER, JONATHAN L.;HEMMI, GREGORY W.;MODY, TARAK D. |
分类号 |
A61K31/40;A61K41/00;A61K49/00;A61K49/06;A61K49/08;A61K51/04;A61L2/00;A61P35/00;A61P43/00;C07D487/22;C07H17/02;C07H21/00;(IPC1-7):C07D487/22;C07F9/652 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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