1,4-BENZOTHIAZEPINE DERIVATIVES

摘要

¢Object! An object of the invention is to provide compounds having a myocardial KD (Kinetic cell death)-inhibiting effect without being accompanied by a cardiodepressant effect. ¢Construction! A 1,4-benzothiazepine derivative represented by the following Formula ¢I!: wherein each of substituent groups is defined as follows: R represents H or a C1 - C3 lower alkoxy group; X represents O or H2; n represents 1 or 2; R1 represents H, a substituted phenyl group wherein the substituent group is OH or a C1-C3 lower alkoxy group, a C1 - C3 lower alkoxy group, wherein R2 represents a C1 - C3 aryl group, and ph represents a phenyl group, or a pharmaceutically acceptable salt thereof. 34